Recent papers discussing “function” in eukaryotic genomes

ENCODE Project Consortium et al. 2012. An integrated encyclopedia of DNA elements in the human genome. Nature 489: 57-74.

Graur D, Zheng Y, Price N, Azevedo RB, Zufall RA, Elhaik E. 2013. On the immortality of television sets: “function” in the human genome according to the evolution-free gospel of ENCODE. Genome Biol Evol. 5:578-590.

Eddy S. 2012. The C-value paradox, junk DNA and ENCODE. Curr Biol. 22:R898– R899.

Eddy SR. 2013. The ENCODE project: missteps overshadowing a success. Curr. Biol. 23: R259-61.

Eddy SR. 2013. Is junk DNA bunk? A critique of ENCODE. Proc Natl Acad Sci U S A. 2013 Apr 2;110(14):5294-300.

Kellis M et al. 2014. Defining functional DNA elements in the human genome. Proc Natl Acad Sci U S A. 2014 Apr 29;111(17):6131-8.

Niu D-K, Jiang L. 2013. Can ENCODE tell us how much junk DNA we carry in our genome? Biochem Biophys Res Commun. 430:1340–1343.

Palazzo AF and Gregory TR. 2014. The Case for Junk DNA. PLoS Gentics 10 (5): e1004351

Doolittle, WF, Brunet TDP, Linquist S, Gregory TR (2014). Distinguishing between “function” and “effect” in genome biology. Genome Biol Evol (2014) doi: 10.1093/gbe/evu098

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